mCAT Got YouR TEF?

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mCAT got youR TEF?

TEF and RTEF-1 Binding to the Smooth Muscle -Actin Gene Distinguishes Myofibroblasts and Adult Smooth Muscle Cells Adult smooth muscle cells are highly plastic and can exhibit a range of phenotypes in response to different environmental and developmental cues. Their phenotypes can range from quiescent highly contractile cells with high levels of characteristic contractile protein isoforms, to h...

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MCAT elements and the TEF-1 family of transcription factors in muscle development and disease.

MCAT elements are located in the promoter-enhancer regions of cardiac, smooth, and skeletal muscle-specific genes including cardiac troponin T, beta-myosin heavy chain, smooth muscle alpha-actin, and skeletal alpha-actin, and play a key role in the regulation of these genes during muscle development and disease. The binding factors of MCAT elements are members of the transcriptional enhancer fa...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 2007

ISSN: 0009-7330,1524-4571

DOI: 10.1161/circresaha.107.164053